A non-hallucinogenic analogue of LSD (2-bromo-lysergic acid diethylamide) with no significant 5-HT2A receptor activity. Studied as a preventive treatment for cluster headache, BOL-148 produces headache-frequency reductions without psychedelic effects — providing strong evidence that psilocybin's therapeutic action in headache disorders is neurological rather than psychological. (Karst et al., Cephalalgia, 2010)
BOL-148 is a non-hallucinogenic analogue of LSD (2-bromo-lysergic acid diethylamide) with no significant 5-HT2A receptor activity. Studied as a preventive treatment for cluster headache, BOL-148 produces headache-frequency reductions without psychedelic effects — providing strong evidence that psilocybin's therapeutic action in headache disorders is neurological rather than psychological. (Karst et al., Cephalalgia, 2010)
See: Cluster Headaches (/conditions/cluster-headaches).
BOL-148 is key evidence that cluster headache relief from psychedelics does not require a psychedelic experience — the mechanism is likely direct modulation of trigeminal or serotonin pathways.