GlossaryBOL-148

BOL-148

A non-hallucinogenic analogue of LSD (2-bromo-lysergic acid diethylamide) with no significant 5-HT2A receptor activity. Studied as a preventive treatment for cluster headache, BOL-148 produces headache-frequency reductions without psychedelic effects — providing strong evidence that psilocybin's therapeutic action in headache disorders is neurological rather than psychological. (Karst et al., Cephalalgia, 2010)

Full Explanation

BOL-148 is a non-hallucinogenic analogue of LSD (2-bromo-lysergic acid diethylamide) with no significant 5-HT2A receptor activity. Studied as a preventive treatment for cluster headache, BOL-148 produces headache-frequency reductions without psychedelic effects — providing strong evidence that psilocybin's therapeutic action in headache disorders is neurological rather than psychological. (Karst et al., Cephalalgia, 2010)

See: Cluster Headaches (/conditions/cluster-headaches).

Why It Matters

BOL-148 is key evidence that cluster headache relief from psychedelics does not require a psychedelic experience — the mechanism is likely direct modulation of trigeminal or serotonin pathways.

Related Terms

5-HT2A receptor

Back to Glossary

Explore More Terms

Psilocybin

A naturally occurring psychedelic compound found in certain mushrooms that produces altered states of consciousness.

Psilocin

The pharmacologically active compound that psilocybin converts to in the body, responsible for psychedelic effects.

Ego Death

A temporary dissolution of the sense of self during a psychedelic experience, often described as profound and transformative.

Set and Setting

The combination of mindset (set) and environment (setting) that shapes a psychedelic experience.

Microdosing

Taking sub-perceptual doses of psilocybin on a regular schedule for subtle cognitive and emotional benefits.

Mycelium

The vegetative part of a fungus, consisting of a network of fine white filaments that eventually produces mushrooms.