Psilocybin Mushroom Species

Over 200 mushroom species across multiple genera are known to contain psilocybin, the psychoactive compound responsible for psychedelic effects. The genus Psilocybe contains the vast majority of species used in both traditional ceremonial contexts and modern clinical research — including P. cubensis, the species behind nearly every major psilocybin trial at institutions like Johns Hopkins and Imperial College London.

Species differ fundamentally from strains. A species is a biologically distinct organism with unique genetics, habitat preferences, and alkaloid profiles. A strain is a cultivated variety within a single species — like how Fuji and Granny Smith are strains of apple (Malus domestica). Most strains in our strain directory are varieties of Psilocybe cubensis.

Potency varies dramatically between species. Psilocybe azurescens contains up to 1.78% psilocybin by dry weight — roughly 3x the concentration of average P. cubensis specimens (0.5–0.8%). This means a dose that produces mild effects with one species could produce an overwhelming experience with another. Always confirm species identification and adjust dosing accordingly using the dosage guide.

The table and cards below cover the primary psilocybin-containing species with documented research or significant traditional use. For legal considerations related to species cultivation and possession, see the legal status tracker.