CSTC circuit
Cortico-striato-thalamo-cortical circuit — a neural feedback loop connecting the orbitofrontal cortex, caudate nucleus, thalamus, and anterior cingulate cortex. Chronically hyperactive and "locked" in OCD, generating intrusive thoughts and compulsive responses. Psilocybin's proposed mechanism in OCD is normalisation of fronto-striatal connectivity within this loop — distinct from its default mode network disruption mechanism in depression.
Full Explanation
The CSTC (cortico-striato-thalamo-cortical) circuit is a neural feedback loop connecting the orbitofrontal cortex, caudate nucleus, thalamus, and anterior cingulate cortex. Chronically hyperactive and "locked" in OCD, it generates intrusive thoughts and compulsive responses. Psilocybin's proposed mechanism in OCD is normalisation of fronto-striatal connectivity within this loop — distinct from its default mode network disruption mechanism in depression.
See: OCD (/conditions/ocd).
Why It Matters
The CSTC circuit explains why OCD may respond to psilocybin through a different pathway than depression — fronto-striatal normalisation rather than DMN disruption.
Related Terms
Explore More Terms
Psilocybin
A naturally occurring psychedelic compound found in certain mushrooms that produces altered states of consciousness.
Psilocin
The pharmacologically active compound that psilocybin converts to in the body, responsible for psychedelic effects.
Ego Death
A temporary dissolution of the sense of self during a psychedelic experience, often described as profound and transformative.
Set and Setting
The combination of mindset (set) and environment (setting) that shapes a psychedelic experience.
Microdosing
Taking sub-perceptual doses of psilocybin on a regular schedule for subtle cognitive and emotional benefits.
Mycelium
The vegetative part of a fungus, consisting of a network of fine white filaments that eventually produces mushrooms.