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Psilocybin-assisted therapy: the complete protocol
What it is, how it works, the three-phase protocol, legal status, costs, and how to find a licensed facilitator.
Read guide 25 min read
From preparation to integration, learn how to approach psilocybin safely and with intention. Citation-backed and reviewed by PsyBear Editorial.
What it is, how it works, the 3-phase protocol, legal status, costs, and how to find a licensed facilitator.
Clinical evidence: MADRS and remission by trial, DMN mechanism, psilocybin vs SSRIs. Strain picks on Best for Depression.
What the research shows: Grob & Griffiths (existential/death anxiety), social anxiety data, amygdala & fear extinction. Strain picks: Best for Anxiety.
NYU/JHU RCT results, 83% reduction in heavy drinking days, 48% abstinence at 32 weeks. Protocol, access, and safety.
Evidence across nicotine, alcohol, opioids, and cocaine — Johns Hopkins 80% nicotine abstinence, mechanisms, and access.
Fear extinction mechanisms, Phase I/II trial data, Australia TGA 2023 prescription pathway, and how to access supervised treatment.
Protocols, dosage, benefits, safety, and the latest research. The complete 2026 guide.
Evidence-based review of lasting effects and risks — afterglow, HPPD, psychosis risk factors, and harm-reduction steps.
Legal jurisdictions, formats, costs, screening, facilitator credentials, red flags, integration, and how to choose safely.
Head-to-head clinical comparison of psilocybin and SSRIs — mechanism, remission rates, side effects, and who each treatment suits.
Clinical models, duration, access, and who each modality suits — ketamine clinics today vs psilocybin programs in Oregon and Colorado.
Legal access decision guide: service centers, healing centers, facilitator rules, cost, travel, and who each state suits.
Therapy-use comparison by condition fit, evidence, mechanism, legal access, cost, and screening risks.
Hub for side-by-side therapy comparisons: psilocybin vs ketamine, MDMA, legal access states, and treatment fit.
Patient guide for people who have tried two or more antidepressants: evidence, candidacy, protocols, and access.
Evidence and access guide for veterans exploring psilocybin for PTSD, moral injury, and legal supervised programs.
5-HT2A blunting, drug-by-drug SSRI interaction profiles, observational survey findings, and medically supervised transition guidance.
Medication and substance interaction hub covering contraindications, blunting, rescue agents, cannabis, alcohol, and tapering context.
Therapy-dose SSRI interaction guide: blunting, washout timelines, serotonin-syndrome context, and supervised taper planning.
Why lithium is a hard contraindication with psilocybin: seizure case reports, bipolar context, and safer next steps.
How cannabis can intensify psilocybin, raise anxiety risk, and complicate harm-reduction planning during a session.
Why MAOIs can intensify psilocybin, which medications count, washout caveats, and why ayahuasca is not a casual safety analogy.
Benzos as rescue medication, chronic-use blunting, sedation risks, and why abrupt tapering before a session is unsafe.
Adderall, Vyvanse, Ritalin, Concerta, atomoxetine, and what supervised protocols consider before dosing day.
Set and setting, dosage safety, and how to reduce risk for a positive experience.
What to do in the days and hours before a journey: diet, mindset, and environment.
How to support someone on a journey — and when to sit for others.
A structured guide to process, understand, and apply psychedelic insights — domains, journal prompts, and support.
Respectful behavior in group and ceremonial settings with sacrament.
Keep your mushrooms potent, safe, and fresh with proper storage methods.
Basics of cultivating psilocybin mushrooms at home, legally and safely.