CYP enzyme (CYP2D6 / CYP1A2)
Cytochrome P450 enzymes responsible for metabolising psilocin and many psychiatric medications in the liver. CYP2D6 is strongly inhibited by fluoxetine (Prozac) and paroxetine (Paxil), slowing their own clearance and potentially affecting psilocybin metabolism. CYP1A2 is strongly inhibited by fluvoxamine (Luvox), which may unpredictably increase psilocin blood levels — making that combination pharmacokinetically risky. Relevant when combining psilocybin with any psychiatric medication.
Full Explanation
CYP enzymes (CYP2D6 and CYP1A2) are cytochrome P450 enzymes responsible for metabolising psilocin and many psychiatric medications in the liver. CYP2D6 is strongly inhibited by fluoxetine (Prozac) and paroxetine (Paxil), slowing their own clearance and potentially affecting psilocybin metabolism. CYP1A2 is strongly inhibited by fluvoxamine (Luvox), which may unpredictably increase psilocin blood levels — making that combination pharmacokinetically risky. Relevant when combining psilocybin with any psychiatric medication.
See: Microdosing on SSRIs (/guides/microdosing-on-ssris).
Why It Matters
Understanding CYP enzymes is essential for anyone considering psilocybin while on SSRIs or other psychiatric medications — interactions can alter both drug levels and trip intensity.
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Psilocybin
A naturally occurring psychedelic compound found in certain mushrooms that produces altered states of consciousness.
Psilocin
The pharmacologically active compound that psilocybin converts to in the body, responsible for psychedelic effects.
Ego Death
A temporary dissolution of the sense of self during a psychedelic experience, often described as profound and transformative.
Set and Setting
The combination of mindset (set) and environment (setting) that shapes a psychedelic experience.
Microdosing
Taking sub-perceptual doses of psilocybin on a regular schedule for subtle cognitive and emotional benefits.
Mycelium
The vegetative part of a fungus, consisting of a network of fine white filaments that eventually produces mushrooms.