A microdosing schedule: one day on, two days off, then repeat. Named after researcher James Fadiman.
The Fadiman Protocol is one of the best-known microdosing schedules. Developed by psychologist and researcher James Fadiman, it involves taking a sub-perceptual dose of psilocybin (typically 0.1–0.3g dried mushrooms) on Day 1, then taking Days 2 and 3 off, and repeating the cycle.
The two rest days allow you to notice any subtle effects and avoid building tolerance. Many microdosers use the "off" days to compare mood, focus, and creativity. The protocol is simple and well-suited to beginners.
People often follow the protocol for 4–8 weeks, then take a break of 2–4 weeks before resuming. Fadiman and others recommend journaling to track effects. The protocol is psilocybin-only (no Lion's Mane or niacin stack), unlike the Stamets Stack.
The Fadiman Protocol is referenced in microdosing guides, dosage pages, and FAQs. Having a glossary entry helps readers who see "Fadiman" or "every 3 days" understand the schedule and how it compares to other protocols.