Paul Stamets' microdosing protocol: psilocybin plus Lion's Mane and niacin, usually 4 days on and 3 days off.
The Stamets Stack is a microdosing protocol developed by mycologist Paul Stamets. It combines a small dose of psilocybin (e.g. 0.1–0.2g dried) with Lion's Mane mushroom (200–500mg) and niacin (vitamin B3, often 100–200mg, starting lower to assess flush tolerance) on the same days.
Stamets recommends 4 days on, 3 days off: take the stack Monday through Thursday and rest Friday through Sunday. This differs from the Fadiman Protocol (1 day on, 2 off). The goal is to support neuroplasticity and cognitive function, with Lion's Mane and niacin proposed to complement psilocybin.
Niacin in these doses often causes a temporary flushing sensation (warmth, redness); starting at 50–100mg and increasing gradually can help. It is generally considered harmless but can be uncomfortable.
No RCTs directly compare the Stamets Stack to Fadiman or placebo. Anecdotal reports and some small studies support microdosing generally; the added Lion's Mane and niacin are based on Stamets' hypotheses.
The Stamets Stack appears in microdosing guides, FAQs, and product descriptions. A clear definition helps readers choose between protocols and understand dosing (Lion's Mane, niacin) and the 4-on/3-off schedule.