Stamets Stack
Paul Stamets' microdosing protocol: psilocybin plus Lion's Mane and niacin, usually 4 days on and 3 days off.
Full Explanation
The Stamets Stack is a microdosing protocol developed by mycologist Paul Stamets. It combines a small dose of psilocybin (e.g. 0.1–0.2g dried) with Lion's Mane mushroom (200–500mg) and niacin (vitamin B3, often 100–200mg, starting lower to assess flush tolerance) on the same days.
Schedule
Stamets recommends 4 days on, 3 days off: take the stack Monday through Thursday and rest Friday through Sunday. This differs from the Fadiman Protocol (1 day on, 2 off). The goal is to support neuroplasticity and cognitive function, with Lion's Mane and niacin proposed to complement psilocybin.
Niacin Flush
Niacin in these doses often causes a temporary flushing sensation (warmth, redness); starting at 50–100mg and increasing gradually can help. It is generally considered harmless but can be uncomfortable.
Evidence
No RCTs directly compare the Stamets Stack to Fadiman or placebo. Anecdotal reports and some small studies support microdosing generally; the added Lion's Mane and niacin are based on Stamets' hypotheses.
Why It Matters
The Stamets Stack appears in microdosing guides, FAQs, and product descriptions. A clear definition helps readers choose between protocols and understand dosing (Lion's Mane, niacin) and the 4-on/3-off schedule.
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Explore More Terms
Psilocybin
A naturally occurring psychedelic compound found in certain mushrooms that produces altered states of consciousness.
Psilocin
The pharmacologically active compound that psilocybin converts to in the body, responsible for psychedelic effects.
Ego Death
A temporary dissolution of the sense of self during a psychedelic experience, often described as profound and transformative.
Set and Setting
The combination of mindset (set) and environment (setting) that shapes a psychedelic experience.
Microdosing
Taking sub-perceptual doses of psilocybin on a regular schedule for subtle cognitive and emotional benefits.
Mycelium
The vegetative part of a fungus, consisting of a network of fine white filaments that eventually produces mushrooms.