GlossaryPulse regimen

Pulse regimen

A dosing schedule used in cluster headache and migraine trials — typically three doses of psilocybin (~10 mg each), administered approximately five days apart, over a two-week period. Distinct from the single high-dose sessions used in depression and PTSD protocols. The therapeutic effect in headache disorders does not correlate with the intensity of the psychedelic experience, suggesting a direct neurological mechanism rather than a psychotherapy-mediated one. (Schindler et al., Journal of Neurological Sciences, 2024)

Full Explanation

A pulse regimen is a dosing schedule used in cluster headache and migraine trials — typically three doses of psilocybin (~10 mg each), administered approximately five days apart, over a two-week period. Distinct from the single high-dose sessions used in depression and PTSD protocols. The therapeutic effect in headache disorders does not correlate with the intensity of the psychedelic experience, suggesting a direct neurological mechanism rather than a psychotherapy-mediated one. (Schindler et al., Journal of Neurological Sciences, 2024)

See: Cluster Headaches (/conditions/cluster-headaches).

Why It Matters

The pulse regimen shows that headache protocols differ from depression protocols — multiple smaller doses, not one high-dose session — and support a neurological rather than psychological mechanism.

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