Current psilocybin laws and regulations in Colorado
Colorado became the second U.S. state to legalize psilocybin when voters passed Proposition 122 (Natural Medicine Health Act) in November 2022. The law decriminalizes personal use, possession, cultivation, and sharing of psilocybin, DMT, ibogaine, and mescaline (excluding peyote) for adults 21 and older. Colorado also has a regulated system for licensed healing centers and facilitators to provide supervised psilocybin services. Commercial retail sales remain prohibited, and Denver had previously decriminalized psilocybin in 2019.
Denver becomes the first U.S. city to decriminalize psilocybin mushrooms.
Colorado voters approve statewide legalization of natural psychedelics.
Personal use and possession of psilocybin becomes legal for adults 21+.
Colorado begins licensing psilocybin healing centers.
Regulated access to DMT and mescaline expected to begin.
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