Current psilocybin laws and regulations in Missouri
Psilocybin remains a controlled substance in Missouri with no legal access pathway today — but Missouri saw the most recent legislative movement of any prohibition state covered here. On 2 April 2026, after four years of failed attempts, the Missouri House passed HB 1717 and sent it to the Senate for the first time. The bill would allocate $2 million for psilocybin research grants, require the Department of Mental Health to partner with a university or FDA-affiliated research institute, and allow veterans aged 21 and over with physician documentation of a qualifying condition to receive psilocybin in a supervised clinical setting. A substantially similar Senate vehicle, SB 1682, was filed the same session. Neither has become law, and psilocybin is illegal in Missouri until one does.
Would have exempted people 21 and over with PTSD, major depressive disorder, a substance use disorder, or end-of-life care needs from state penalties when enrolled in a clinical trial. It did not pass.
The first time the measure cleared the House and reached the Senate. It funds $2 million in research grants and would allow qualifying veterans 21+ to receive psilocybin in a supervised clinical setting with physician documentation.
HB 1717 and the similar SB 1682 remain pending. Until one is enacted, psilocybin possession stays illegal statewide with no therapeutic exemption.
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