Current psilocybin laws and regulations in South Carolina
Psilocybin is a Schedule I controlled substance in South Carolina under S.C. Code §44-53-190, and there is no decriminalization, no therapeutic-access program, and no city deprioritization resolution anywhere in the state. South Carolina does differ from many prohibition states in one practical respect: simple possession of a Schedule I substance that is not a narcotic is charged as a misdemeanor rather than a felony, with a first offense carrying up to $1,000, up to six months in jail, or both, and a second offense up to $2,000, up to one year, or both. That is a meaningfully lighter classification than Ohio's or Nevada's felony treatment — but it is still a criminal charge, and no reform legislation is currently active.
Psilocybin, along with MDMA, DMT, ibogaine and LSD, is Schedule I under both South Carolina and federal law.
Under S.C. Code §44-53-370, possession of a non-narcotic Schedule I substance is a misdemeanor: up to $1,000 and/or six months for a first offense, up to $2,000 and/or one year for a second.
The General Assembly recessed on 14 May 2026 without advancing psychedelic reform. No psilocybin decriminalization, research, or therapeutic-access bill is currently active.
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